Homology Folding of Proteins

by Subhashini Srinivasan

The homology modeling method is an important tool in protein engineering and drug design when an experimental 3D structure is not available. Development of distance geometry-based homology modeling, offers a holistic approach to protein modeling thus expanding the scope of this method to protein threading and protein folding. This book is the first of its kind to give a complete account of the field, including structural principles and sequence-to-structural relationships in the PDB. This book is intended for use by biologists and modelers who are new to homology modeling methods, and serves as a good starting point for further research.